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本文引用的文献

1
Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels.缓释口服沙丁胺醇和氨茶碱治疗夜间哮喘：肺功能和血浆药物水平的夜间变化关系
Thorax. 1980 Jul;35(7):526-30. doi: 10.1136/thx.35.7.526.
2
Circadian variation in adrenergic responses in asthmatic subjects.哮喘患者肾上腺素能反应的昼夜节律变化。
Clin Sci (Lond). 1982 Apr;62(4):349-54. doi: 10.1042/cs0620349.
3
Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol.夜间哮喘与循环中的肾上腺素、组胺和皮质醇的变化
N Engl J Med. 1980 Jul 31;303(5):263-7. doi: 10.1056/NEJM198007313030506.
4
Single-dose slow-release aminophylline at night prevents nocturnal asthma.夜间单剂量缓释氨茶碱可预防夜间哮喘。
Lancet. 1982 Feb 6;1(8267):299-301. doi: 10.1016/s0140-6736(82)91566-5.
5
On observing patterns of airflow obstruction in chronic asthma.关于观察慢性哮喘气流阻塞模式的研究
Br J Dis Chest. 1977 Apr;71(2):73-86. doi: 10.1016/0007-0971(77)90086-9.

皮下注射特布他林与脆性哮喘或明显清晨峰谷现象的控制

Subcutaneous terbutaline and control of brittle asthma or appreciable morning dipping.

作者信息

Ayres J, Fish D R, Wheeler D C, Wiggins J, Cochrane G M, Skinner C

出版信息

Br Med J (Clin Res Ed). 1984 Jun 9;288(6432):1715-6. doi: 10.1136/bmj.288.6432.1715.

DOI:10.1136/bmj.288.6432.1715
PMID:6428511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1441578/
Abstract

In a pilot study two patients with brittle asthma and two with morning dipping received terbutaline or a placebo administered subcutaneously either by continuous infusion or in injections every six hours. In two patients brittle asthma was completely suppressed by terbutaline 1 mg/day given by either method. In the two others early morning dipping responded only to continuous subcutaneous infusions of terbutaline 12 mg/day. Terbutaline administered subcutaneously may be an effective treatment in asthmatic patients who show important diurnal variations in air flow.

摘要

在一项初步研究中，两名脆性哮喘患者和两名晨降型哮喘患者接受了特布他林或安慰剂皮下注射治疗，给药方式为持续输注或每6小时注射一次。两名脆性哮喘患者通过上述任何一种方法给予1毫克/天的特布他林后，脆性哮喘完全得到控制。另外两名患者的晨降型哮喘仅对12毫克/天的特布他林皮下持续输注有反应。皮下注射特布他林可能是气流存在显著昼夜变化的哮喘患者的一种有效治疗方法。