活化T和B淋巴细胞分化抗原（ACA-1）在淋巴样和非淋巴样肿瘤细胞上的表达。

Expression of the differentiation antigen of activated T and B lymphocytes (ACA-1) on cells of lymphoid and nonlymphoid tumors.

作者信息

Nesterenko V G, Yermakov G P, Fontalin L N, Rubakova E I

出版信息

Cell Immunol. 1984 Jul;86(2):472-8. doi: 10.1016/0008-8749(84)90402-7.

Abstract

In cytotoxicity and indirect immunofluorescence tests an antiserum to ACA-1 (activated cell antigen) reacted with 58-100% of actively proliferating cells from tumors of lymphoid (EL-4 T lymphoma, MOPC 104E plasmacytoma) and nonlymphoid origin (AH-22 hepatoma, Sa-1 and MCh-11 sarcomas, F2 mammary cancer). Absorption of anti-ACA-1 serum with tumor cells sharply reduced its activity both against the cells of all these neoplasms and against normal activated T and B lymphocytes. Absorption with proliferating murine cells from the brain of embryos and the retina of neonates or with similar (nonproliferating) cells from adult mice did not affect the activity of the antiserum. It is concluded that ACA-1 is expressed on actively proliferating cells of the tumors studied.

摘要

在细胞毒性和间接免疫荧光试验中，一种抗ACA - 1（活化细胞抗原）的抗血清与来自淋巴样（EL - 4 T淋巴瘤、MOPC 104E浆细胞瘤）和非淋巴样来源（AH - 22肝癌、Sa - 1和MCh - 11肉瘤、F2乳腺癌）肿瘤的58 - 100%的活跃增殖细胞发生反应。用肿瘤细胞吸收抗ACA - 1血清会显著降低其对所有这些肿瘤细胞以及正常活化T和B淋巴细胞的活性。用来自胚胎脑和新生小鼠视网膜的增殖性鼠细胞或来自成年小鼠的类似（非增殖性）细胞进行吸收，并不影响抗血清的活性。得出的结论是，ACA - 1在所研究肿瘤的活跃增殖细胞上表达。