Buice R G, Niell H B, Sidhu P, Gurley B J
Cancer Chemother Pharmacol. 1984;13(1):1-4. doi: 10.1007/BF00401436.
The disposition kinetics of the cancer chemotherapeutic agent mitomycin C have been studied in six male patients receiving mitomycin C in combination with cisplatin and vinblastine for non-oat cell carcinoma of the lung. Following rapid IV administration of mitomycin C (10 mg/m2), serum concentration-time course data were biexponential, with biologic half-lives of 46.2 +/- 12.1 min (mean +/- SD). Pharmacokinetic analysis of data by the CSTRIP and NONLIN digital computer programs generated parameters which suggested extensive distribution (V area = 656.8 +/- 169.8 ml X kg-1, mean +/- SD) and, as reported for other alkylating agents, rapid elimination (total body clearance = 10.3 +/- 3.2 ml X kg-1 X min-1, mean +/- SD). Interpatient variations in pharmacokinetic parameters were relatively small, suggesting that close monitoring of mitomycin C therapy might be unnecessary in patients with normal renal and hepatic function.
对6名男性患者进行了研究，这些患者因非小细胞肺癌接受丝裂霉素C联合顺铂和长春碱治疗，以了解癌症化疗药物丝裂霉素C的处置动力学。快速静脉注射丝裂霉素C（10 mg/m²）后，血清浓度-时间过程数据呈双指数，生物半衰期为46.2±12.1分钟（平均值±标准差）。通过CSTRIP和NONLIN数字计算机程序对数据进行药代动力学分析，得出的参数表明分布广泛（V面积=656.8±169.8 ml·kg⁻¹，平均值±标准差），并且如其他烷化剂报道的那样，消除迅速（全身清除率=10.3±3.2 ml·kg⁻¹·min⁻¹，平均值±标准差）。患者间药代动力学参数的差异相对较小，这表明对于肾功能和肝功能正常的患者，可能无需密切监测丝裂霉素C治疗。
