Chandrasekar P H, Schell R F, LeFrock J L, Rolston K V, Francisco M
Chemotherapy. 1984;30(3):165-9. doi: 10.1159/000238263.
Cefsulodin was the most active of the cephalosporins and exhibited 4-16 times more activity than carbenicillin or ticarcillin against 50 clinical isolates of Pseudomonas aeruginosa. Azlocillin and piperacillin showed good activity, while tobramycin was the most effective aminoglycoside. The activity of cefsulodin was unaltered by increases in inocula, but resistance was induced easily. When combined with gentamicin, no synergistic or antagonistic activity was observed against multiply resistant isolates.
头孢磺啶是头孢菌素类中活性最强的，对50株铜绿假单胞菌临床分离株的活性比羧苄西林或替卡西林高4至16倍。阿洛西林和哌拉西林表现出良好的活性，而妥布霉素是最有效的氨基糖苷类药物。头孢磺啶的活性不受接种量增加的影响，但很容易诱导出耐药性。与庆大霉素联合使用时，对多重耐药分离株未观察到协同或拮抗活性。
