Takano K, Hizuka N, Shizume K, Ling N C
Endocrinol Jpn. 1984 Feb;31(1):41-8. doi: 10.1507/endocrj1954.31.41.
Synthetic human pancreatic GRF (hpGRF-44) was administered as an iv bolus to 139 normal children of short stature and 63 patients with GH deficiency. After a dose of 1 and 2 micrograms hpGRF-44/kg BW, mean plasma GH levels peaked at 15 and 30 min, respectively, with corresponding values of 32.2 +/- 3.6 and 31.8 +/- 2.4 (+/- SE) ng/ml in normal but short children. There were no differences according to sex or age in plasma GH response to hpGRF-44 between the ages of 4 and 18 years. A similar plasma GH response was observed when 2 micrograms hpGRF-44/kg BW was administered two hours after lunch. The overall plasma GH response was greater than that of insulin-induced hypoglycemia and was similar to that obtained in the glucagon-propranolol test. Thirty-five of 63 patients with GH deficiency did not respond to a 2 micrograms hpGRF-44/kg BW. However, plasma GH increases to greater than 5 ng/ml occurred in the remaining 28 patients. Their mean GH level reached a peak at 90 min with a value of 8.8 +/- 0.8 ng/ml. These results suggest that hpGRF-44 is useful for evaluating pituitary GH reserve in children of short stature and that some patients with GH deficiency, diagnosed on the basis of established tests, have GH responses to hpGRF-44.
将合成的人胰生长激素释放因子（hpGRF - 44）静脉推注给予139名身材矮小的正常儿童和63名生长激素缺乏患者。给予1微克/千克体重和2微克/千克体重的hpGRF - 44后，正常身材矮小儿童的血浆生长激素水平分别在15分钟和30分钟达到峰值，相应值分别为32.2±3.6和31.8±2.4（±标准误）纳克/毫升。4至18岁儿童中，血浆生长激素对hpGRF - 44的反应在性别和年龄上无差异。午餐后两小时给予2微克/千克体重的hpGRF - 44时，观察到类似的血浆生长激素反应。总体血浆生长激素反应大于胰岛素诱导的低血糖反应，且与胰高血糖素 - 普萘洛尔试验得到的反应相似。63名生长激素缺乏患者中有35名对2微克/千克体重的hpGRF - 44无反应。然而，其余28名患者的血浆生长激素升高至大于5纳克/毫升。他们的平均生长激素水平在90分钟达到峰值，值为8.8±0.8纳克/毫升。这些结果表明，hpGRF - 44可用于评估身材矮小儿童的垂体生长激素储备，并且一些根据既定试验诊断为生长激素缺乏的患者对hpGRF - 44有生长激素反应。
