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Blood group substances, T6 antigen and heterochromatin pattern as species markers in the nude mouse/human skin model.

作者信息

Graem N, Dabelsteen E, Tommerup N

出版信息

Exp Cell Biol. 1984;52(4):251-9. doi: 10.1159/000163268.

DOI:10.1159/000163268
PMID:6428941
Abstract

Antibodies to blood group antigens and to human T6 antigen and the DNA-specific fluorochrome D287/170 were applied to human skin transplanted to nude mice and to the surrounding murine skin. It was found that the two epithelia maintained their characteristic, different blood group B antigen distributions and heterochromatin patterns. Furthermore, it was shown that human Langerhans' cells persisted in the grafted epidermis. During an observation period of until 48 weeks after transplantation only one of 32 grafts showed signs of invasion by murine epidermis.

摘要

相似文献

1
Blood group substances, T6 antigen and heterochromatin pattern as species markers in the nude mouse/human skin model.
Exp Cell Biol. 1984;52(4):251-9. doi: 10.1159/000163268.
2
Localization of the defect in skin diseases analyzed in the human skin graft-nude mouse model.在人皮肤移植裸鼠模型中分析皮肤病缺损的定位
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Migration of Langerhans cells into human epidermis of "reconstructed" skin, normal skin, or healing skin, after grafting onto the nude mouse.将“重建”皮肤、正常皮肤或愈合皮肤移植到裸鼠身上后,朗格汉斯细胞向其人类表皮的迁移。
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Defined in situ enumeration of T6 and HLA-DR expressing epidermal Langerhans cells: morphologic and methodologic aspects.原位定量表达T6和HLA-DR的表皮朗格汉斯细胞:形态学和方法学方面
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Migration of Langerhans cells into the epidermis of human skin grafted into nude mice.朗格汉斯细胞迁移至移植到裸鼠体内的人皮肤表皮中。
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Human epidermal Langerhans cells replenish skin xenografts and are depleted by alloreactive T cells in vivo.人表皮朗格汉斯细胞可补充皮肤异种移植物,并在体内被同种异体反应性 T 细胞耗竭。
J Immunol. 2011 Aug 1;187(3):1142-9. doi: 10.4049/jimmunol.1001491. Epub 2011 Jun 22.

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