Ingebrigtsen K, Nafstad I, Andersen R A
Gen Pharmacol. 1984;15(3):201-4. doi: 10.1016/0306-3623(84)90159-9.
Radiolabelled paraquat (bis-N-(14C)methyl-4,4'-bipyridylium chloride) was administered intravenously to pregnant rats and guinea-pigs and examined by the whole body autoradiography method. Male rats were examined for comparison with the same method. The results showed that the radiolabelled compound was rapidly distributed throughout the tissues, with the highest concentrations in the cartilage, kidney, lung, spleen, salivary gland and skin. High concentrations were found in the placenta and throughout the fetuses 0.5 hr after the administration.
将放射性标记的百草枯（双-N-(14C)甲基-4,4'-联吡啶鎓氯化物）静脉注射给怀孕的大鼠和豚鼠，并采用全身放射自显影法进行检测。使用相同方法检测雄性大鼠以作比较。结果显示，放射性标记化合物迅速分布于全身组织，在软骨、肾脏、肺、脾脏、唾液腺和皮肤中的浓度最高。给药后0.5小时，在胎盘和整个胎儿体内发现了高浓度的该化合物。
