Sannes E, Nafstad I
Acta Pharmacol Toxicol (Copenh). 1980 Jan;46(1):47-50. doi: 10.1111/j.1600-0773.1980.tb02418.x.
The tissue distribution of 4-14C-lynestrenol (17 alpha-ethynyl-oestr-4-en-17 beta-ol) following oral administration to pregnant rats was studied by whole body autoradiography and liquid scintillation counting. Pregnant females were sacrificed on days 10, 12, 14 and 19 of gestation, in each case 5 hours after oral administration of 43 microCi 4-14C-lynestrenol per animal. The isotopelabelled compound was distributed throughout most tissues, including the fetuses. The highest concentrations were found in the liver, while there was lower activity in the fatty tissues and the activity in the fetuses was comparable with that in the brain. The placental transfer was verified by the results of liquid scintillation counting. The concentration of labelled substance in the fetuses increased with the duration of pregnancy.
通过全身放射自显影和液体闪烁计数法研究了怀孕大鼠口服4-¹⁴C-炔诺醇（17α-乙炔基-4-烯-17β-醇）后的组织分布。在妊娠第10、12、14和19天处死怀孕的雌性大鼠，每种情况都是在每只动物口服43微居里4-¹⁴C-炔诺醇5小时后进行。这种同位素标记的化合物分布于大多数组织，包括胎儿。在肝脏中发现浓度最高，而在脂肪组织中的活性较低，胎儿中的活性与大脑中的相当。液体闪烁计数结果证实了胎盘转运。胎儿中标记物质的浓度随怀孕时间延长而增加。
