Stratton J A, Braly P S, DiSaia P J
Gynecol Oncol. 1984 Jun;18(2):145-9. doi: 10.1016/0090-8258(84)90021-0.
The sensitivity of 12 human tumors to various chemotherapeutic agents was measured in the 6-day subrenal capsule xenograft assay. All of the tumors were adenocarcinomas: 9 ovarian, 2 colon, and one endometrial. Doxorubicin, cisplatin, melphalan, 5- fluorouracil , methotrexate, and vinblastine sulfate were tested for antineoplastic activity on all tumors. In addition, a prostaglandin synthetase inhibitor, sodium ibuprofen, was assayed for cytostatic activity and for the ability to enhance the cytotoxic activity of melphalan and vinblastine sulfate. The response of the tumors to the cytotoxic agents were variable, but 5 of the 12 tumors showed a significant reduction of growth when the animals were treated with sodium ibuprofen alone. The addition of ibuprofen to the chemotherapeutic agents did not significantly alter the therapeutic activity of melphalan, but decreased the effectiveness of vinblastine in one case. When ibuprofen was given in combination with a cytotoxic drug, the primary cytoreductive effect was that of the cytotoxic agent.
在为期6天的肾包膜下异种移植试验中，检测了12种人类肿瘤对各种化疗药物的敏感性。所有肿瘤均为腺癌：9例卵巢癌、2例结肠癌和1例子宫内膜癌。对所有肿瘤测试了阿霉素、顺铂、美法仑、5-氟尿嘧啶、甲氨蝶呤和硫酸长春碱的抗肿瘤活性。此外，还检测了一种前列腺素合成酶抑制剂布洛芬钠的细胞生长抑制活性以及增强美法仑和硫酸长春碱细胞毒活性的能力。肿瘤对细胞毒药物的反应各不相同，但12例肿瘤中有5例在单独用布洛芬钠治疗动物时显示生长显著减缓。在化疗药物中添加布洛芬并没有显著改变美法仑的治疗活性，但在1例中降低了长春碱的有效性。当布洛芬与细胞毒药物联合使用时，主要的细胞减灭作用是由细胞毒药物产生的。
