Giordano C, De Santo N G, Carella C, Capodicasa G, Amato G, Nuzzi F, Mioli V, Bazzato G, De Simone V, Tarchini A
Int J Artif Organs. 1984 May;7(3):119-22.
Thyroid function was measured in 30 healthy subjects and 84 patients with various degrees of nephron loss (GRF: 70 +/- 15 m/min, 30 +/- 16 ml/min, 10 +/- 7 ml/min and 2.1 +/- 1.3 ml/min). A low T3 and T4 syndrome is evident when GRF is reduced to 30 +/- 16 ml/min while a blunted TSH response is detected earlier in the course of nephron loss. T3 response to TRH was normal and FT4 was not affected by renal dysfunction. The data indicate that in nephron loss hypothalamic-pituitary abnormalities occur.
对30名健康受试者和84名不同程度肾单位丢失的患者（肾小球滤过率：70±15毫升/分钟、30±16毫升/分钟、10±7毫升/分钟和2.1±1.3毫升/分钟）进行了甲状腺功能检测。当肾小球滤过率降至30±16毫升/分钟时，低T3和T4综合征明显，而在肾单位丢失过程中更早检测到促甲状腺激素反应迟钝。T3对促甲状腺激素释放激素的反应正常，游离甲状腺素不受肾功能障碍影响。数据表明，在肾单位丢失时会出现下丘脑 - 垂体异常。
