Mendenhall N P, Parsons J T, Cassisi N J, Million R R
Int J Radiat Oncol Biol Phys. 1984 May;10(5):627-37. doi: 10.1016/0360-3016(84)90293-1.
Squamous cell carcinomas of the nasal vestibule are essentially skin cancers that require special therapeutic considerations because of the regional anatomy. They have sometimes been considered poorly suited for treatment by irradiation because of potential or actual cartilage and/or bone invasion and therefore have been treated by surgical resection, sometimes producing defects that are difficult to reconstruct satisfactorily. From 1966 to April 1980, 13 patients with squamous cell carcinoma of the nasal vestibule were treated with radiotherapy at the University of Florida. Eight lesions were de novo; 5 were recurrent after 1 or more surgical procedures. Treatment consisted of radium needle implantation and/or external beam therapy. Neck management was individualized. All de novo and 4 of 5 recurrent lesions were controlled locally. Cosmetic results were good in patients with de novo lesions. There were no instances of significant cartilage or soft tissue necrosis despite cartilage involvement by tumor in 6 cases.
鼻前庭鳞状细胞癌本质上是皮肤癌，由于其局部解剖结构，需要特殊的治疗考量。由于可能存在或实际发生的软骨和/或骨侵犯，它们有时被认为不太适合放疗，因此一直通过手术切除进行治疗，有时会产生难以令人满意地修复的缺损。1966年至1980年4月，佛罗里达大学对13例鼻前庭鳞状细胞癌患者进行了放射治疗。8个病变为原发；5个是在1次或多次手术之后复发的。治疗包括镭针植入和/或外照射治疗。颈部处理是个体化的。所有原发病变以及5个复发病变中的4个在局部得到了控制。原发病变患者的美容效果良好。尽管6例肿瘤侵犯了软骨，但没有出现明显的软骨或软组织坏死情况。
