Harada Hinako, Ishikawa Yojiro, Tanaka Shohei, Kishida Keita, Umezawa Rei, Yamamoto Takaya, Takahashi Noriyoshi, Takeda Kazuya, Suzuki Yu, Jingu Keiichi
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, 980-8574 Japan.
Int Cancer Conf J. 2022 Apr 8;11(3):184-187. doi: 10.1007/s13691-022-00546-x. eCollection 2022 Jul.
Radiation therapy (RT) is one of the definitive treatments for early-stage nasal vestibular carcinoma and has similar local control rates to resection surgery. There are various methods, including external beam RT and brachytherapy. This report describes a case who showed local control for more than 5 years after brachytherapy alone using Au-198 grains for nasal vestibular carcinoma. A 68-year-old Japanese man complained of swelling and pain in his left nasal cavity. He was diagnosed with squamous cell carcinoma (SCC) (cT1N0M0, stage I). An elevated mass of 8 mm in long diameter was found inside the left nasal cavity. Since the patient selected brachytherapy, nine Au-198 grains 185 mBq were permanently injected percutaneously under local anesthesia, and 85 Gy was prescribed. Grade three dermatitis was observed as an acute adverse event. After 2 years, mild telangiectasia of the left nasal skin and epilation of nasal hair in the left nasal cavity was regarded as late adverse events. The patient continues to keep a complete response for 5 years. For small nasal vestibular SCC, brachytherapy with Au-198 grains might be a good option.
放射治疗（RT）是早期鼻前庭癌的确定性治疗方法之一，其局部控制率与切除手术相似。有多种方法，包括外照射放疗和近距离放射治疗。本报告描述了一例仅使用金-198籽粒进行鼻前庭癌近距离放射治疗后局部控制超过5年的病例。一名68岁的日本男性主诉左鼻腔肿胀和疼痛。他被诊断为鳞状细胞癌（SCC）（cT1N0M0，I期）。在左鼻腔内发现一个长径8毫米的隆起肿物。由于患者选择了近距离放射治疗，在局部麻醉下经皮永久性注射9颗185毫贝可的金-198籽粒，处方剂量为85戈瑞。观察到三级皮炎为急性不良事件。2年后，左鼻皮肤轻度毛细血管扩张和左鼻腔鼻毛脱落被视为晚期不良事件。患者持续保持完全缓解状态达5年。对于小型鼻前庭鳞状细胞癌，使用金-198籽粒进行近距离放射治疗可能是一个不错的选择。
