Nielsen J A, Moore K E
J Neurochem. 1984 Aug;43(2):593-6. doi: 10.1111/j.1471-4159.1984.tb00941.x.
The effects of thyrotropin-releasing hormone (TRH) and its synthetic analog, pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide (MK-771), were determined on the efflux of dihydroxyphenylacetic acid (DOPAC) collected from push-pull cannulae chronically implanted into the lateral cerebral ventricles of rats. Intracerebroventricular and intraperitoneal injections of both peptides increased the efflux of DOPAC. These results suggest that TRH and MK-771 increase the activity of dopaminergic neurons that terminate in periventricular regions.
研究了促甲状腺激素释放激素（TRH）及其合成类似物焦谷氨酸-2-氨基己二酰-组氨酰-噻唑烷-4-羧酰胺（MK-771）对从长期植入大鼠侧脑室的推挽式套管收集的二羟基苯乙酸（DOPAC）流出量的影响。脑室内和腹腔内注射这两种肽均增加了DOPAC的流出量。这些结果表明，TRH和MK-771增加了终止于脑室周围区域的多巴胺能神经元的活性。
