Hiasa Y, Enoki N, Kitahori Y, Konishi N, Shimoyama T
J Natl Cancer Inst. 1984 Jul;73(1):297-9.
Subcutaneous injection of DL-serine increased the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine [(EHEN) CAS: 13147-25-6, 2-(ethylnitrosamino)ethanol]. At the end of the 32-week experiment, the incidences of renal tumors were 95% in rats treated with 1,000 ppm EHEN for 2 weeks and then given three sc injections of DL-serine every 2 weeks, 33% in rats treated with 1,000 ppm EHEN for 2 weeks, and 28% in rats treated with 500 ppm EHEN for 2 weeks and then given three sc injections of DL-serine every 2 weeks. No renal tumors were found in rats treated with 500 ppm EHEN alone or given three sc injections of DL-serine alone every 2 weeks.
皮下注射DL-丝氨酸增加了用500或1000 ppm N-乙基-N-羟乙基亚硝胺[（EHEN），化学物质登记号：13147-25-6，2-（乙基亚硝氨基）乙醇]处理的雄性W大鼠肾小管细胞瘤的数量和大小。在32周实验结束时，接受1000 ppm EHEN处理2周然后每2周皮下注射三次DL-丝氨酸的大鼠肾肿瘤发生率为95%，接受1000 ppm EHEN处理2周的大鼠为33%，接受500 ppm EHEN处理2周然后每2周皮下注射三次DL-丝氨酸的大鼠为28%。单独接受500 ppm EHEN处理或每2周单独皮下注射三次DL-丝氨酸的大鼠未发现肾肿瘤。
