Shirai T, Ohshima M, Masuda A, Tamano S, Ito N
J Natl Cancer Inst. 1984 Feb;72(2):477-82.
The promoting effects of nephrotoxic chemicals, folic acid (FA), N-(3,5-dichlorophenyl)succinimide (NDPS), 2,3-dibromo-1-propanol phosphate (Tris-BP), and basic lead acetate (LAB), on 2-(ethylnitrosamino)ethanol (EHEN)-induced renal carcinogenesis were examined in F344 rats. The rats were treated with 0.1% EHEN in their drinking water for 1 week and then given one of the nephrotoxic chemicals for 35 weeks. FA was injected sc once a week at a dose of 300 mg/kg for the first 8 weeks and thereafter at 100 mg/kg. NDPS, Tris-BP, and LAB were mixed in the diet at concentrations of 0.5, 0.01, and 0.1%, respectively. At week 3 the right kidney was removed to enhance renal neoplasia. Renal cell tumor incidence was significantly increased by both FA and LAB and was slightly increased by NDPS, whereas Tris-BP had no effect. The data show that FA, LAB, and NDPS are promoters of EHEN-induced renal carcinogenesis.
在F344大鼠中研究了肾毒性化学物质、叶酸（FA）、N-（3,5-二氯苯基）琥珀酰亚胺（NDPS）、2,3-二溴-1-丙醇磷酸酯（Tris-BP）和碱式醋酸铅（LAB）对2-（乙基亚硝基氨基）乙醇（EHEN）诱导的肾癌发生的促进作用。大鼠饮用含0.1% EHEN的水1周，然后给予一种肾毒性化学物质35周。FA在前8周每周皮下注射一次，剂量为300 mg/kg，此后为100 mg/kg。NDPS、Tris-BP和LAB分别以0.5%、0.01%和0.1%的浓度混入饲料中。在第3周切除右肾以促进肾肿瘤形成。FA和LAB均显著增加肾细胞肿瘤发生率，NDPS使其略有增加，而Tris-BP无作用。数据表明，FA、LAB和NDPS是EHEN诱导的肾癌发生的促进剂。
