妊娠合并RH血型免疫时的循环胎盘蛋白

Circulating placental proteins in pregnancies complicated by RH isoimmunization.

作者信息

Lee J N, Huang S C, Ouyang P C, Chard T

出版信息

Obstet Gynecol. 1984 Jul;64(1):131-2.

Abstract

Nine pregnant women with Rh isoimmunization who delivered newborns with hydrops fetalis were studied. The placental proteins, pregnancy specific beta 1-glycoprotein (SP1), human placental lactogen, and placental protein 5 (PP5) were measured in maternal serum by radioimmunoassays. The results indicate that both the serum human placental lactogen and PP5 levels were significantly higher than those observed in normal pregnancy. The strikingly higher circulating PP5 levels found in all nine patients with Rh isoimmunization studied suggests that serum PP5 may be specifically elevated in pregnant patients with Rh isoimmunization and hydrops fetalis.

摘要

对9名患有Rh血型免疫的孕妇进行了研究，她们分娩出患有胎儿水肿的新生儿。通过放射免疫分析法测定母血中的胎盘蛋白、妊娠特异性β1-糖蛋白（SP1）、人胎盘催乳素和胎盘蛋白5（PP5）。结果表明，血清人胎盘催乳素和PP5水平均显著高于正常妊娠时观察到的水平。在所有9名研究的Rh血型免疫患者中发现的循环PP5水平显著升高，这表明Rh血型免疫和胎儿水肿的孕妇血清PP5可能会特异性升高。