Tabsh K M
Obstet Gynecol. 1984 Jul;64(1):92-6.
Ossification centers about the fetal knee were identified and measured by ultrasound in 133 nondiabetic patients who underwent amniocentesis for determination of the amniotic fluid lecithin:sphingomyelin ratio (L:S ratio) between 28 and 42 weeks' gestation. A distal femoral epiphysis measuring greater than or equal to 5 mm and a proximal tibial epiphysis measuring 3 mm or greater was seen at 34 to 35 weeks' gestation. A mature lecithin: sphingomyelin ratio (lecithin: sphingomyelin greater than or equal to 2.0) was present with 66, 94, and 100% of proximal tibial epiphysis measuring 0 to 2, 3 to 4, and 5 to 7 mm, respectively. A mature lecithin: sphingomyelin ratio was present with 39, 76, and 95% of distal femoral epiphysis measuring 0 to 2, 3 to 4, and 5 to 7 mm, respectively. These results suggest that in nondiabetic patients, the ossification centers about the fetal knee as measured by ultrasound correlate well with amniotic fluid lecithin: sphingomyelin ratio.
对133例非糖尿病孕妇进行羊膜穿刺术以测定妊娠28至42周羊水卵磷脂:鞘磷脂比值（L:S比值），并通过超声识别和测量胎儿膝关节周围的骨化中心。妊娠34至35周时可见股骨远端骨骺测量值大于或等于5mm，胫骨近端骨骺测量值为3mm或更大。当胫骨近端骨骺分别为0至2、3至4、5至7mm时，成熟的卵磷脂:鞘磷脂比值（卵磷脂:鞘磷脂大于或等于2.0）出现的比例分别为66%、94%和100%。当股骨远端骨骺分别为0至2、3至4、5至7mm时，成熟的卵磷脂:鞘磷脂比值出现的比例分别为39%、76%和95%。这些结果表明，在非糖尿病患者中，通过超声测量的胎儿膝关节周围骨化中心与羊水卵磷脂:鞘磷脂比值密切相关。
