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苯丙胺性厌食症：射频损伤及向猫多巴胺能黑质纹状体束注射6-羟基多巴胺的影响。

Amphetamine anorexia: the effect of radio-frequency lesions and 6-OHDA injections into dopaminergic nigro-striatal bundle in cats.

作者信息

Konopacki J

出版信息

Pol J Pharmacol Pharm. 1983 Nov-Dec;35(6):497-502.

PMID:6429650
Abstract

The effect of radio-frequency (RF) and 6-OHDA lesions of two levels of dopaminergic nigro-striatal bundle on amphetamine anorexia was investigated in 4 groups of cats. RF and 6-OHDA lesions of far-lateral hypothalamus produced significant facilitation of feeding after injection of amphetamine. RF and 6-OHDA destructions of substantia nigra were with slight or without (respectively) effect on amphetamine anorexia. The results suggest that nigrostriatal bundle is not essential for mechanisms mediating amphetamine anorexia.

摘要

在4组猫中研究了两个水平的多巴胺能黑质纹状体束的射频（RF）和6-羟基多巴胺（6-OHDA）损伤对苯丙胺性厌食的影响。远外侧下丘脑的RF和6-OHDA损伤在注射苯丙胺后显著促进进食。黑质的RF和6-OHDA破坏对苯丙胺性厌食分别有轻微影响或无影响。结果表明，黑质纹状体束对于介导苯丙胺性厌食的机制并非必不可少。

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