Konopacki J
Acta Physiol Pol. 1983 Jul-Aug;34(4):409-17.
Far-lateral hypothalamus ( FLH ) and substantia nigra (SN) were destroyed by means of radio-frequency current (RF lesion) or neurotoxically (6-hydroxydopamine injection) in 4 groups of cats. Deficits in osmoregulatory thirst were observed only after RF lesions of FLH . Disturbances in gluco-regulatory eating were observed after RF destructions and injections of 6-hydroxydopamine to the FLH . Both methods of SN damage did not affect the behavioural responses of the animals to regulatory challenges. These results suggest that deficits in behavioural responses to regulatory challenges observed in LH syndrome in cats are not related to the function of the dopaminergic nigro-striatal bundle.
在4组猫中，通过射频电流（射频损伤）或神经毒性方法（注射6-羟基多巴胺）破坏了下丘脑外侧区（FLH）和黑质（SN）。仅在下丘脑外侧区进行射频损伤后才观察到渗透压调节性口渴缺陷。在下丘脑外侧区进行射频破坏和注射6-羟基多巴胺后观察到糖调节性进食障碍。两种破坏黑质的方法均未影响动物对调节性刺激的行为反应。这些结果表明，在猫的下丘脑综合征中观察到的对调节性刺激的行为反应缺陷与多巴胺能黑质纹状体束的功能无关。
