多胺生物合成抑制剂对Dunning R 3327-G前列腺肿瘤的抗生长作用。
Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor.
作者信息
Herr H W, Kleinert E L
出版信息
Prostate. 1984;5(4):439-44. doi: 10.1002/pros.2990050408.
PMID:6429652
Abstract
alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats. Neither DFMO (2%) nor MGBG at a nontoxic dose (15 mg/kg) inhibited tumor growth, but total (47% early cure rate) or near total suppression of growth of established tumors was observed in rats receiving both treatments.
摘要
α-二氟甲基鸟氨酸（DFMO）和甲基乙二醛双脒腙（MGBG）同时给药时，可抑制移植到哥本哈根大鼠体内的邓宁R 3327-G激素抵抗性前列腺腺癌的生长，且具有高毒性。单独使用DFMO（2%）或无毒剂量的MGBG（15毫克/千克）均不能抑制肿瘤生长，但在接受两种治疗的大鼠中，观察到已形成肿瘤的生长被完全（早期治愈率47%）或几乎完全抑制。
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