Gilliam A C, Shen A, Richards J E, Blattner F R, Mushinski J F, Tucker P W
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4164-8. doi: 10.1073/pnas.81.13.4164.
We present here the sequence characterization of a C mu----C delta immunoglobulin (Ig) heavy chain class switch. In the murine IgD-secreting plasmacytoma TEPC 1017, deletion of most of the mu switch recombination region (S mu) and the entire C mu gene occurred in the absence of switch region sequences 5' to C delta. This unique rearrangement resulted from an illegitimate recombination of sequences with only patchy homology to each other. The infrequent and variable nature of illegitimate recombination may explain the low frequency of IgD-secreting plasma cells in normal mouse tissues.
我们在此展示了Cμ向Cδ免疫球蛋白（Ig）重链类别转换的序列特征。在分泌IgD的小鼠浆细胞瘤TEPC 1017中，大部分μ转换重组区（Sμ）和整个Cμ基因的缺失发生在Cδ 5'端缺乏转换区序列的情况下。这种独特的重排是由彼此仅有局部同源性的序列间的非法重组导致的。非法重组的罕见性和多变性可能解释了正常小鼠组织中分泌IgD的浆细胞频率较低的现象。
