Schöpf J, Laurian S, Le P K, Gaillard J M
Pharmacopsychiatry. 1984 May;17(3):79-83. doi: 10.1055/s-2007-1017413.
Ten healthy volunteers were injected i.v. with 5 mg Ro 15-1788, a specific benzodiazepine antagonist, or placebo in a double-blind randomised design. In the EEG, Ro 15-1788 led--with some topographical variations--to a diminution of theta and alpha power, an increase of alpha mean frequency and a decrease of delta mean frequency. In auditory evoked potentials, the N1P2 and P2N2 amplitudes decreased. The electrophysiological changes induced by Ro 15-1788 are consistent with a central stimulant action. Ro 15-1788 induced some slight behavioural and subjective changes.
十名健康志愿者以双盲随机设计静脉注射5毫克Ro 15 - 1788（一种特定的苯二氮䓬拮抗剂）或安慰剂。在脑电图中，Ro 15 - 1788导致——存在一些地形学差异——θ波和α波功率降低，α波平均频率增加，δ波平均频率降低。在听觉诱发电位中，N1P2和P2N2波幅降低。Ro 15 - 1788引起的电生理变化与中枢兴奋作用一致。Ro 15 - 1788引起了一些轻微的行为和主观变化。
