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Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.

作者信息

Laurian S, Gaillard J M, Le P K, Schöpf J

出版信息

Neuropsychobiology. 1984;11(1):55-8. doi: 10.1159/000118052.

DOI:10.1159/000118052
PMID:6429564
Abstract

Brain electrical activity changes induced by Ro 15-1788, an antagonist of central benzodiazepine effects, were investigated in 10 normal subjects. The diazepam-induced sedation, as ascertained by spontaneous EEG, was rapidly reversed after an intravenous injection of 5 mg Ro 15-1788. There appeared to be a good correlation between the EEG and evoked responses modifications; the decrease of the amplitude of the N2 wave may reflect an increase of alertness.

摘要

相似文献

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Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.
Neuropsychobiology. 1984;11(1):55-8. doi: 10.1159/000118052.
2
Reversal of the anticonvulsant effects of diazepam on amygdaloid-kindled seizures by a specific benzodiazepine antagonist: RO 15-1788.
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Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788.苯二氮䓬拮抗剂Ro15 - 1788对犬地西泮脑效应的逆转作用。
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[EEG analysis of the effectiveness of the benzodiazepine antagonist RO 15-1788 after diazepam sedation].[地西泮镇静后苯二氮䓬拮抗剂RO 15 - 1788有效性的脑电图分析]
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RO 15-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability.RO 15 - 1788可拮抗地西泮对人体的中枢作用，而不改变地西泮的生物利用度。
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Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.地西泮在消退程序中诱导的行为释放：Ro 15-1788对其的逆转作用
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Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788.一种特异性苯二氮䓬拮抗剂Ro 15 - 1788可逆转地西泮而非普罗加比的肌肉松弛作用。
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Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.苯二氮䓬拮抗剂Ro 15 - 1788可拮抗小鼠中由次最大剂量戊四氮诱导的惊厥。
Life Sci. 1983 May 30;32(22):2579-84. doi: 10.1016/0024-3205(83)90241-2.

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