Bürrig K F, Kastendieck H
Virchows Arch A Pathol Anat Histopathol. 1984;403(4):413-24. doi: 10.1007/BF00737290.
Five localized fibrous tumours of the pleura (benign mesothelioma) were studied ultrastructurally in order to elucidate their histogenesis. The histological subtypes of this benign fibrous lesion of the visceral pleura, i.e. the cellular, the collagenous, and the hyaline, were separately analysed. The tumours are composed of undifferentiated mesenchymal cells, intermediate and differentiated fibroblasts as well as collagenous interstitial tissue. The varying distribution of these cell elements account for the various histological subtypes. Morphological similarities between the mesenchymal tumour cells and the superficial mesothelial cells, which are always separated from the true tumour tissue by an intact basement membrane, were not observed. The different cellular elements can be regarded as parts of a continuous spectrum of cytodifferentiation, in which the mature fibroblasts are derived via intermediate forms from the undifferentiated cells. It is concluded that the localized fibrous tumours of the pleura arise from immature mesenchymal stem cells, which seems to be normally found in the submesothelial layer of the visceral pleura.
为了阐明其组织发生，对五例局限性胸膜纤维瘤（良性间皮瘤）进行了超微结构研究。对这种脏层胸膜良性纤维性病变的组织学亚型，即细胞型、胶原型和透明型，分别进行了分析。肿瘤由未分化间充质细胞、中间型和成纤维细胞以及胶原性间质组织组成。这些细胞成分的不同分布导致了各种组织学亚型。未观察到间充质肿瘤细胞与浅表间皮细胞之间的形态学相似性，浅表间皮细胞总是通过完整的基底膜与真正的肿瘤组织分隔开。不同的细胞成分可被视为细胞分化连续谱的一部分，其中成熟的成纤维细胞通过中间形式从未分化细胞衍生而来。结论是，胸膜局限性纤维瘤起源于未成熟的间充质干细胞，这些干细胞似乎通常存在于脏层胸膜的间皮下层。
