Degonda F, Gürke L, Pedrinis E, Luscieti P, Solari G M, Martinoli S
Reparto di chirurgia, Ospedale Civico, Lugano.
Helv Chir Acta. 1994 Dec;60(6):919-22.
The localized fibrous tumors of the pleura are rare neoplasms, also known as "benign pleural fibromas" or "localized mesotheliomas", but those names are inaccurate. The tumors are composed of undifferentiated mesenchymal cells, intermediate and differentiated fibroblasts and collagenous interstitial tissue. Their origin is normally the submesothelial layer of the visceral pleura. Mesothelial differentiation is not present. The grading of malignancy doesn't correlate with final outcome, adequacy of surgical excision being the most important factor. This neoplasm may recur but retain its basical histologic features. The positive results for vimentin and negative results for cytokeratin antibodies help to distinguish the localized fibrous tumors from the mesothelioma. We present too cases and their diagnostic possibilities.
胸膜局限性纤维瘤是罕见的肿瘤，也被称为“良性胸膜纤维瘤”或“局限性间皮瘤”，但这些名称并不准确。肿瘤由未分化的间充质细胞、中间型和分化型成纤维细胞以及胶原性间质组织组成。它们通常起源于脏层胸膜的间皮下层。不存在间皮分化。恶性程度分级与最终结果无关，手术切除的充分性是最重要的因素。这种肿瘤可能复发，但保留其基本组织学特征。波形蛋白阳性而细胞角蛋白抗体阴性有助于将局限性纤维瘤与间皮瘤区分开来。我们展示了两个病例及其诊断可能性。
