Glackin K C, Sherwood W C, Hoppe P A, McIntyre K
Vox Sang. 1984;47(1):82-7. doi: 10.1111/j.1423-0410.1984.tb01565.x.
Reliable detection of the weak D (Du) antigen has been a problem for the Groupamatic typing equipment. Using several anti-D sera of known concentration and Du red cells, dose-response curves produced by the Groupamatic revealed variation in the ability to detect the Du antigen by commercial anti-D reagents. Variation in the reactivity of the Du antigen among Du-positive donors was noted. Studies were conducted to determine optimal conditions for the Groupamatic to detect the weakest Du cells. When these conditions were applied to the retesting, 28 cell samples previously found falsely negative by a number of blood centers were accurately detected.
对弱 D（Du）抗原进行可靠检测一直是血型自动分型设备面临的一个问题。使用几种已知浓度的抗 D 血清和 Du 红细胞，血型自动分型设备产生的剂量反应曲线显示，市售抗 D 试剂检测 Du 抗原的能力存在差异。注意到 Du 阳性供体中 Du 抗原反应性的差异。开展了研究以确定血型自动分型设备检测最弱 Du 细胞的最佳条件。将这些条件应用于重新检测时，先前被多个血站误判为阴性的 28 个细胞样本被准确检测出来。
