Quinti I, Pacilli L, Zoli V, De Sanctis G, Mannella E, Bonomo G, De Laurenzi A, Pandolfi F
Acta Haematol. 1984;71(5):310-5. doi: 10.1159/000206607.
We report the case of a 70-year-old female with a lymphocytosis which was casually detected during a routine examination. Immunological studies revealed the expansion of granular lymphocytes (GL) with the following, previously undescribed phenotype: Leu 7+, OKT3+, OKT4+, OKT8-, OKM1+. These cells were tested for their functional activities and found to exert neither helper nor suppressor functions in in vitro tests. Cytotoxic activities demonstrated a strong ADCC and a markedly reduced NK function. 1 year later the clinical course has remained good without any treatment and we suggest that this case should be classified as an abnormal expansion of GL, despite the OKT4 positivity of the cells. Our data point out the importance of a careful immunological study of cells from these rare patients and suggest the existence of a normal GL population expressing the OKT4 phenotype, which is possibly expanded in this patient.
我们报告了一例70岁女性病例，其淋巴细胞增多在常规检查中偶然被发现。免疫学研究显示颗粒淋巴细胞（GL）扩增，具有以下此前未描述的表型：Leu 7 +、OKT3 +、OKT4 +、OKT8 -、OKM1 +。对这些细胞的功能活性进行了检测，发现在体外试验中它们既不发挥辅助功能也不发挥抑制功能。细胞毒性活性显示出强烈的抗体依赖细胞介导的细胞毒性（ADCC）且自然杀伤（NK）功能明显降低。1年后，未经任何治疗，临床病程仍良好，我们建议尽管这些细胞OKT4呈阳性，但该病例应归类为GL异常扩增。我们的数据指出了对这些罕见患者的细胞进行仔细免疫学研究的重要性，并提示存在表达OKT4表型的正常GL群体，该群体在该患者中可能发生了扩增。
