Smolianskaia A Z, Spasibina T V
Antibiotiki. 1984 May;29(5):391-3.
The mitomycin C levels in the blood of patients subjected to prolonged intravenous injection of the drug in 200-300 ml of isotonic sodium chloride solution for 15-50 minutes were determined in the microbiological test system consisting of E. coli and 1.5 per cent of agar in the meat-peptone broth with restricted contents of the nutrients. Such administration of the drug usually provided lower blood levels than intravenous injections of the drug in analogous doses. However, the drug renal excretion was also less intensive. It suggested that the drug administered for a prolonged period was more completely absorbed by the host tissues. This was confirmed by much lower blood levels of the drug, when the tumors were large, as compared to those in patients with insignificant residues of the tumor tissue after surgical resections. The curves of mitomycin C distribution in the blood indicate that the pharmacokinetics of the drug in patients with tumors is a multi-factorial function.
在由大肠杆菌和营养成分受限的肉蛋白胨肉汤中1.5%的琼脂组成的微生物检测系统中，测定了在200 - 300毫升等渗氯化钠溶液中持续静脉注射丝裂霉素C 15 - 50分钟的患者血液中的丝裂霉素C水平。与以类似剂量静脉注射该药物相比，这种给药方式通常会使血液水平较低。然而，药物经肾脏排泄的强度也较小。这表明长时间给药的药物被宿主组织吸收得更完全。这一点在肿瘤较大的患者中得到了证实，与手术切除后肿瘤组织残留较少的患者相比，前者血液中的药物水平要低得多。丝裂霉素C在血液中的分布曲线表明，该药物在肿瘤患者体内的药代动力学是一个多因素函数。
