[肾盂及输尿管肿瘤术后化疗的研究]

[A study of post-operative chemotherapy for renal pelvic and ureteral tumors].

作者信息

Numasawa K, Kakizaki H, Takamizawa A, Kubota Y, Suzuki K

出版信息

Gan To Kagaku Ryoho. 1984 Jul;11(7):1501-5.

Abstract

A study was made of the relationship between post-operative chemotherapy and metastasis and recurrence of bladder tumor in 9 patients with renal pelvic and ureteral tumors. Within 6 months on average, post-operative metastasis was found in 33.3% (3 out of 9 cases). Differentiating according to the type of chemotherapy, the rate of occurrence of metastasis was 50% (2 out of 4) in the case of treatment with either a combination of FT-207, chromomycin A3 and cytosine arabinoside, or with FT-207 alone, while it was 100% (2 out of 2) in stage pT2 and pT3 patients. For combined administration of CDDP, FT-207 and cytosine arabinoside, or for that of CDDP and neocarzinostatin, on the other hand, the rate of occurrence of metastasis was only 20% (1 out of 5) in stage pT2 and pT3 patients, while CDDP administration was found to be effective for preventing post-operative metastasis. However, while recurrence of bladder tumor was found in a total of 3 out of 9 cases (33.3%), recurrence occurred in 40% (2 out of 5) of the cases treated with CDDP. The administration of CDDP was therefore not found to be effective for preventing recurrence of bladder tumor.

摘要

对9例肾盂及输尿管肿瘤患者术后化疗与膀胱肿瘤转移及复发的关系进行了研究。平均在6个月内，33.3%（9例中的3例）出现术后转移。根据化疗类型区分，使用FT - 207、色霉素A3和阿糖胞苷联合治疗或仅使用FT - 207治疗时，转移发生率为50%（4例中的2例），而在pT2和pT3期患者中为100%（2例中的2例）。另一方面，对于顺铂（CDDP）、FT - 207和阿糖胞苷联合给药，或顺铂与新制癌菌素联合给药，在pT2和pT3期患者中转移发生率仅为20%（5例中的1例），且发现顺铂给药对预防术后转移有效。然而，虽然9例中有3例（33.3%）出现膀胱肿瘤复发，但在接受顺铂治疗的病例中有40%（5例中的2例）复发。因此，未发现顺铂给药对预防膀胱肿瘤复发有效。