Watanabe K, Ishida T, Yoshitomi F, Tanaka K
Atherosclerosis. 1984 May-Jun;51(2-3):151-61. doi: 10.1016/0021-9150(84)90163-1.
The synthesis of prostaglandin I2 (PGI2) was found to decrease with age in cultured, porcine aortic endothelial cells. Arachidonic acid (AA)-induced PGI2 synthesis per cell at low cell density was higher than that at high cell density. PGI2 synthesis by cultured porcine aortic smooth muscle cells, without exogenous AA, was higher than that by cultured porcine aortic endothelial cells, while AA-induced PGI2 synthesis by cultured porcine aortic medial smooth muscle cells was lower than that by cultured endothelial cells. PGI2 synthesis by cultured smooth muscle cells incubated with fibrinogen degradation products (FDPs) for 24 h decreased. After incubation with FDPs for 24 h, AA-induced PGI2 synthesis by endothelial cells also diminished. These data suggest that PGI2 synthesis in the vascular wall is affected by FDPs, and that FDPs probably play an important role in the initiation of atherosclerosis.
研究发现，在培养的猪主动脉内皮细胞中，前列腺素I2（PGI2）的合成随年龄增长而减少。在低细胞密度下，花生四烯酸（AA）诱导的单个细胞PGI2合成高于高细胞密度时的合成。在无外源性AA的情况下，培养的猪主动脉平滑肌细胞的PGI2合成高于培养的猪主动脉内皮细胞，而培养的猪主动脉中膜平滑肌细胞经AA诱导后的PGI2合成低于培养的内皮细胞。用纤维蛋白原降解产物（FDPs）孵育培养的平滑肌细胞24小时后，其PGI2合成减少。内皮细胞经FDPs孵育24小时后，AA诱导的PGI2合成也减少。这些数据表明，血管壁中的PGI2合成受FDPs影响，且FDPs可能在动脉粥样硬化的起始过程中起重要作用。
