抗炎药物可调节纤维蛋白原降解产物诱导的肥大细胞组胺释放。
Anti-inflammatory drugs modulate histamine release from mast cells induced by fibrinogen degradation products.
作者信息
Wojtecka-Lukasik E, Stachurska J, Kopeć M, Maśliński S
机构信息
Department of Biochemistry, Institute of Rheumatology, Warsaw, Poland.
出版信息
Ann Rheum Dis. 1988 Apr;47(4):328-32. doi: 10.1136/ard.47.4.328.
The products resulting from proteolytic degradation of human fibrinogen (FDP) were found to induce the release of histamine from rat peritoneal mast cells. Low molecular weight, dialysable peptides (FDP) showed the highest dose dependent, histamine releasing activity. Histamine release induced by FDP was effectively inhibited by the gold compound auranofin at a concentration of 10(-5)-10(-7) mol/l and also by the non-steroidal anti-inflammatory drugs BW 755c, timegadine, medosan, naproxen, and aspirin at the higher concentration range of 10(-4)-10(-6) mol/l. It is concluded that the release of histamine from mast cells may be modulated to some extent by anti-inflammatory drugs, especially auranofin, BW 755c and timegadine, a functional property which may be beneficial in the management of joint disease.
研究发现，人纤维蛋白原蛋白水解降解产物（FDP）可诱导大鼠腹膜肥大细胞释放组胺。低分子量、可透析的肽（FDP）表现出最高的剂量依赖性组胺释放活性。FDP诱导的组胺释放可被金化合物金诺芬在10（-5）-10（-7）mol/l浓度下有效抑制，也可被非甾体抗炎药BW 755c、替马加定、美多心安、萘普生和阿司匹林在10（-4）-10（-6）mol/l的较高浓度范围内有效抑制。得出结论：肥大细胞组胺释放可能在一定程度上受抗炎药调节，尤其是金诺芬、BW 755c和替马加定，这一功能特性可能对关节疾病的治疗有益。
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