Kukita H, Hiwada K, Kokubu T
Atherosclerosis. 1984 May-Jun;51(2-3):261-7. doi: 10.1016/0021-9150(84)90173-4.
Serum cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I, A-II and B concentrations were measured in 109 first-degree relatives of patients with angiographically defined coronary artery disease (CAD). Age- and sex-matched healthy factory employees were chosen as a control group. Male relatives of the CAD patients had significantly higher serum triglyceride and apoB levels, and significantly lower serum HDL-C and apoA-I levels than the controls. Female relatives of the CAD patients also showed similar differences in serum HDL-C, apoA-I and apoB levels. Discriminant analysis indicated that apolipoproteins were better discriminators than lipids in both patients with CAD and their relatives. In univariate analysis, the best discriminator was apoB between male relatives and the controls, and apoA-I between female relatives and the controls. The percentage of exact classification achieved using three variables (serum cholesterol, triglyceride and HDL-C) was 74% in male relatives and 70% in female relatives. By adding variables of apoA-I and apoB, the percentage of correctly classified subjects was increased to 82% and 80%, respectively. These results indicate that serum apolipoprotein abnormalities are prevalent in relatives of the CAD patients. These abnormalities may explain the familial aggregation of CAD.
对109名经血管造影确诊为冠心病（CAD）患者的一级亲属测定了血清胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）以及载脂蛋白（apo）A-I、A-II和B的浓度。选取年龄和性别匹配的健康工厂员工作为对照组。CAD患者的男性亲属血清甘油三酯和apoB水平显著高于对照组，血清HDL-C和apoA-I水平显著低于对照组。CAD患者的女性亲属在血清HDL-C、apoA-I和apoB水平上也表现出类似差异。判别分析表明，在CAD患者及其亲属中，载脂蛋白比脂质更能有效区分。单变量分析中，男性亲属与对照组之间最佳区分指标是apoB，女性亲属与对照组之间是apoA-I。使用三个变量（血清胆固醇、甘油三酯和HDL-C）进行精确分类的比例，男性亲属为74%，女性亲属为70%。通过添加apoA-I和apoB变量，正确分类的受试者比例分别提高到82%和80%。这些结果表明，血清载脂蛋白异常在CAD患者亲属中普遍存在。这些异常可能解释了CAD的家族聚集性。
