Helliwell M, Coombes E J, Moody B J, Batstone G F
Br J Rheumatol. 1984 Aug;23(3):190-4. doi: 10.1093/rheumatology/23.3.190.
Thyroxine-binding prealbumin (TBPA) concentrations were measured in 54 patients with rheumatoid arthritis (RA) and 50 control subjects. TBPA levels were significantly depressed in the RA patients, of whom 15 had values below the laboratory reference range. Although significant negative correlations were seen between TBPA and the erythrocyte sedimentation rate, C-reactive protein and alpha 1-antichymotrypsin measurements, TBPA levels showed little relationship to disease activity as assessed clinically. On the other hand, RA patients with reduced TBPA had an increased frequency of associated anthropometric and serum visceral protein abnormalities indicating nutritional impairment. TBPA is probably subjected to diverse stimuli in patients with RA and should not be considered to act as a 'pure' negative acute phase reactant.
对54例类风湿性关节炎（RA）患者和50名对照者测定了甲状腺素结合前白蛋白（TBPA）浓度。RA患者的TBPA水平显著降低，其中15例的值低于实验室参考范围。虽然TBPA与红细胞沉降率、C反应蛋白及α1抗糜蛋白酶测定值之间存在显著负相关，但TBPA水平与临床评估的疾病活动度关系不大。另一方面，TBPA降低的RA患者伴有身体测量和血清内脏蛋白异常的频率增加，提示存在营养损害。RA患者的TBPA可能受到多种刺激，不应被视为一种“纯粹”的负性急性期反应物。
