Morrow C P
CA Cancer J Clin. 1984 Jul-Aug;34(4):220-31. doi: 10.3322/canjclin.34.4.220.
According to animal, human, and laboratory data, the major, life-threatening risks to the woman from exogenous estrogens are neoplastic and cardiovascular. These risks are, to some extent, related to dose, duration of therapy, and certain predisposing individual factors. Except for endometrial carcinoma, the risks have not been adequately studied and are therefore not defined. Because of their potential magnitude collectively, no intelligent assessment of the risk-benefit ratios can be can be carried out until the effect, if any, on the susceptibility for breast carcinoma, ovarian carcinoma, and cardiovascular disease is determined.
根据动物、人体和实验室数据，外源性雌激素给女性带来的主要危及生命的风险是肿瘤和心血管方面的。这些风险在一定程度上与剂量、治疗持续时间以及某些个体易感因素有关。除子宫内膜癌外，其他风险尚未得到充分研究，因此尚无明确界定。由于这些风险总体上可能很大，在确定其对乳腺癌、卵巢癌和心血管疾病易感性的影响（如果有影响的话）之前，无法对风险效益比进行明智的评估。
