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1
Purified plasminogen activating factor produced by malignant lymphoid cells abrogates lymphocyte cytotoxicity.恶性淋巴细胞产生的纯化纤溶酶原激活因子可消除淋巴细胞的细胞毒性。
Clin Exp Immunol. 1984 Jun;56(3):701-8.
2
Synthesis and release of plasminogen activator by lymphoid cell lines of malignant origin and its effect on lymphocyte cytotoxicity.恶性起源的淋巴细胞系纤溶酶原激活物的合成与释放及其对淋巴细胞细胞毒性的影响。
Exp Biol. 1985;43(4):277-85.
3
NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma.用白细胞介素-15或CpG寡脱氧核苷酸刺激的自然杀伤细胞可增强利妥昔单抗对B细胞淋巴瘤的细胞毒性作用。
Exp Hematol. 2008 Jan;36(1):69-77. doi: 10.1016/j.exphem.2007.08.012. Epub 2007 Oct 23.
4
Mechanism of cell-mediated cytotoxicity at the single cell level. VI. Direct assessment of the cytotoxic potential of human peripheral blood non-lytic effector-target cell conjugates.单细胞水平的细胞介导细胞毒性机制。VI. 人外周血非裂解效应细胞-靶细胞共轭物细胞毒性潜力的直接评估。
J Immunol. 1984 Feb;132(2):594-8.
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Phorbol esters enhance spontaneous cytotoxicity of human lymphocytes, abrogate Fc receptor expression, and inhibit antibody-dependent lymphocyte-mediated cytotoxicity.佛波酯可增强人淋巴细胞的自发细胞毒性，消除Fc受体表达，并抑制抗体依赖性淋巴细胞介导的细胞毒性。
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Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines.
Exp Hematol. 1984 Oct;12(9):688-93.
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Antibody- and interferon-dependent killer cells are part of the NK cell receptor positive subpopulation of human peripheral blood cells.抗体依赖性和干扰素依赖性杀伤细胞是人类外周血细胞中自然杀伤细胞受体阳性亚群的一部分。
Clin Exp Immunol. 1983 Jul;53(1):101-8.
8
Clonal expansion of human B73.1-positive natural killer cells or large granular lymphocytes exerting strong antibody-dependent and -independent cytotoxicity and occasionally lectin-dependent cytotoxicity.人类B73.1阳性自然杀伤细胞或大颗粒淋巴细胞的克隆性扩增，这些细胞具有强大的抗体依赖性和非依赖性细胞毒性，偶尔还具有凝集素依赖性细胞毒性。
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9
Synergistic inhibition of human cell-mediated cytotoxicity by complement component antisera indicates that target cell lysis may result from an enzymatic cascade involving granzymes and perforin.补体成分抗血清对人细胞介导的细胞毒性的协同抑制表明，靶细胞裂解可能源于涉及颗粒酶和穿孔素的酶促级联反应。
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10
Stable expression of the transfected HIV-1 env gene in a human B cell line: characterization of gp120-expressing clones and immunobiological studies.转染的HIV-1 env基因在人B细胞系中的稳定表达：表达gp120的克隆的特性及免疫生物学研究。
Virology. 1993 Feb;192(2):447-57. doi: 10.1006/viro.1993.1060.

本文引用的文献

1
Comparison of the relative fibrinogenolytic, fibrinolytic and thrombolytic properties of tissue plasminogen activator and urokinase in vitro.组织型纤溶酶原激活剂与尿激酶在体外的相对纤维蛋白溶解、纤溶及溶栓特性比较
Thromb Haemost. 1981 Jun 30;45(3):225-9.
2
Further studies on the mitogenic and immune-modulating effects of plasminogen activator.纤溶酶原激活剂的促有丝分裂和免疫调节作用的进一步研究。
Immunology. 1982 Apr;45(4):715-20.
3
Immunological characterization of plasminogen activator activities in human tissues and body fluids.人体组织和体液中纤溶酶原激活剂活性的免疫学特性
J Lab Clin Med. 1981 Apr;97(4):477-86.
4
Epstein-Barr virus (EBV)--lymphoid cell interactions. II. The influence of the EBV replication cycle on natural killing and antibody-dependent cellular cytotoxicity against EBV-infected cells.爱泼斯坦-巴尔病毒（EBV）与淋巴细胞的相互作用。II. EBV复制周期对针对EBV感染细胞的自然杀伤及抗体依赖性细胞毒性的影响。
Clin Exp Immunol. 1982 Jun;48(3):589-601.
5
Sera from patients with undifferentiated nasopharyngeal carcinoma contain a factor which abrogates specific Epstein-Barr virus antigen-induced lymphocyte response.未分化鼻咽癌患者的血清中含有一种能消除特定爱泼斯坦-巴尔病毒抗原诱导的淋巴细胞反应的因子。
Int J Cancer. 1982 Apr 15;29(4):407-12. doi: 10.1002/ijc.2910290408.
6
Isolation and purification of a tissue plasminogen activator and its comparison with urokinase.组织型纤溶酶原激活剂的分离纯化及其与尿激酶的比较。
Biochemistry. 1969 Jan;8(1):79-86. doi: 10.1021/bi00829a013.
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Delayed cutaneous hypersensitivity reactions to autologous extracts of Burkitt-lymphoma cells.
N Engl J Med. 1970 Apr 2;282(14):776-80. doi: 10.1056/NEJM197004022821404.
8
Cell-mediated immune responses to virus infections and virus-induced tumours.针对病毒感染和病毒诱导肿瘤的细胞介导免疫反应。
Br Med Bull. 1967 Jan;23(1):60-5. doi: 10.1093/oxfordjournals.bmb.a070518.
9
Delayed cutaneous sensitivity reactions to autologous Burkitt lymphoma protein extract. Results of a prospective two and a half year study.对自体伯基特淋巴瘤蛋白提取物的迟发性皮肤敏感反应。一项为期两年半的前瞻性研究结果。
Clin Exp Immunol. 1971 Dec;9(6):713-9.
10
Differences in the binding to fibrin of urokinase and tissue plasminogen activator.尿激酶和组织型纤溶酶原激活剂与纤维蛋白结合的差异。
Thromb Diath Haemorrh. 1972 Aug 31;28(1):65-74.

恶性淋巴细胞产生的纯化纤溶酶原激活因子可消除淋巴细胞的细胞毒性。

Purified plasminogen activating factor produced by malignant lymphoid cells abrogates lymphocyte cytotoxicity.

作者信息

Sundar S K, Bergeron J, Menezes J

出版信息

Clin Exp Immunol. 1984 Jun;56(3):701-8.

PMID:6430612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536014/
Abstract

Immunosuppression is a generally observed phenomenon in patients with malignancies. Here we report that plasminogen activating factor (PAF) produced by human (P3HR-1) and simian (B95-8) lymphoid cells of malignant origin abrogates lymphocyte cytotoxicity. PAF has been purified from Epstein-Barr (EB) virus genome carrying lymphocyte cytotoxicity. PAF has been purified from Epstein-Barr (EB) virus genome carrying lymphoid lines by affinity chromatography using lysine-Sepharose columns. Purified PAF consistently inhibited Killer cell activity against the following targets: K-562, EB virus superinfected Raji cells and in vitro EB virus transformed autologous B lymphocytes. Furthermore PAF also inhibited the antibody-dependent cellular cytotoxicity. The results presented also indicate that PAF affects the effector lymphocytes and not the target cells. Taken together, these observations emphasize the importance of factors such as PAF, released by malignant cells, as inhibitors/modulators of immune mechanisms effective against tumour cells.

摘要

免疫抑制是恶性肿瘤患者中普遍观察到的一种现象。在此我们报告，源自人类（P3HR-1）和猿猴（B95-8）的恶性淋巴样细胞产生的纤溶酶原激活因子（PAF）可消除淋巴细胞的细胞毒性。PAF已从携带淋巴细胞细胞毒性的爱泼斯坦-巴尔（EB）病毒基因组中纯化出来。通过使用赖氨酸-琼脂糖柱的亲和层析法，已从携带淋巴样细胞系的EB病毒基因组中纯化出PAF。纯化的PAF持续抑制杀伤细胞对以下靶标的活性：K-562、EB病毒超感染的拉吉细胞以及体外EB病毒转化的自体B淋巴细胞。此外，PAF还抑制抗体依赖性细胞毒性。所呈现的结果还表明，PAF影响效应淋巴细胞而非靶细胞。综上所述，这些观察结果强调了诸如PAF等由恶性细胞释放的因子作为对肿瘤细胞有效的免疫机制的抑制剂/调节剂的重要性。