Further studies on the mitogenic and immune-modulating effects of plasminogen activator.
作者信息
Wainberg M A, Israel E, Margolese R G
出版信息
Immunology. 1982 Apr;45(4):715-20.
Abstract
Plasminogen activator (PA), an enzyme which is secreted in large quantities by certain types of tumour cells, is an apparent lymphocyte mitogen. Treatment of mouse spleen cells with anti-Thy-1.2 serum plus complement prevents responsiveness, indicating that T cells are being stimulated to divide. In addition to the foregoing, we have shown that PA has the capacity to interfere with certain types of cell-mediated cytotoxicity and natural killer cell reactions in which tumour cells are employed as targets. These results suggest that PA may play an immune-modulating role which may be of importance in tumour self-defense.
摘要
相似文献
1
Further studies on the mitogenic and immune-modulating effects of plasminogen activator.
Immunology. 1982 Apr;45(4):715-20.
2
Plasminogen activator is an apparent lymphocyte mitogen.
J Immunol. 1981 Apr;126(4):1415-20.
3
Studies on interactions between plasminogen activator-containing fluids and avain and murine lymphocytes.
Dev Comp Immunol. 1981 Fall;5(4):649-60. doi: 10.1016/s0145-305x(81)80039-0.
4
氧化有丝分裂原刺激中反应性细胞的特征。I. 增殖反应需要Ia⁺细胞和Ly-1⁺2⁺细胞。
J Immunol. 1980 Jun;124(6):2693-9.
5
尿激酶型和组织型纤溶酶原激活剂作为人成纤维细胞的生长因子。
Exp Cell Res. 1994 Jul;213(1):286-94. doi: 10.1006/excr.1994.1200.
6
Plasminogen activators in nude mice xenotransplanted with human tumorigenic cells.
Invasion Metastasis. 1995;15(1-2):22-33.
7
纤溶酶诱导的腱生蛋白-C蛋白水解：T淋巴细胞衍生的尿激酶型纤溶酶原激活剂的调节作用及其对T淋巴细胞黏附、激活和细胞聚集的影响
J Immunol. 1997 Feb 1;158(3):1051-60.
8
9
自然杀伤细胞激活机制：Qa5⁺自然杀伤细胞与淋巴细胞之间的关系
J Immunol. 1981 Jan;126(1):331-4.
10
通过用正常豚鼠血清处理从小鼠淋巴细胞悬液中选择性去除T细胞功能。
J Immunol. 1980 Apr;124(4):1599-602.
引用本文的文献
1
抗尿激酶型纤溶酶原激活剂单克隆抗体对人恶性脑肿瘤细胞系增殖的体外抑制作用
Br J Cancer. 1998 Dec;78(12):1578-85. doi: 10.1038/bjc.1998.726.
2
体外人类单核细胞趋化性需要尿激酶受体。
J Clin Invest. 1994 Apr;93(4):1380-7. doi: 10.1172/JCI117114.
3
巨噬细胞中的胃蛋白酶样酶及其在免疫系统中的作用。
Clin Exp Immunol. 1984 Oct;58(1):206-12.
4
恶性淋巴细胞产生的纯化纤溶酶原激活因子可消除淋巴细胞的细胞毒性。
Clin Exp Immunol. 1984 Jun;56(3):701-8.
5
人自然杀伤细胞（大颗粒淋巴细胞）产生纤溶酶原激活物。
J Exp Med. 1984 Mar 1;159(3):935-51. doi: 10.1084/jem.159.3.935.
本文引用的文献
1
鸡自然杀伤细胞活性：靶细胞分析及抗胸腺细胞血清对效应细胞的影响。
Infect Immun. 1981 Mar;31(3):1078-85. doi: 10.1128/iai.31.3.1078-1085.1981.
2
Plasminogen activator is an apparent lymphocyte mitogen.
J Immunol. 1981 Apr;126(4):1415-20.
3
在培养的小鼠淋巴瘤中，H-2抗原逐渐丧失，同时由莫洛尼白血病病毒决定的细胞表面抗原增加。
J Natl Cancer Inst. 1973 Feb;50(2):347-62. doi: 10.1093/jnci/50.2.347.
4
蛋白酶作为促细胞分裂剂。胰蛋白酶和链霉蛋白酶对小鼠及人类淋巴细胞的作用。
Exp Cell Res. 1974 Oct;88(2):388-94. doi: 10.1016/0014-4827(74)90257-2.
5
与致癌转化相关的纤维蛋白溶解。细胞因子（一种纤溶酶原激活剂）的部分纯化及特性鉴定。
J Biol Chem. 1974 Jul 10;249(13):4295-305.
6
Mitogenic action of trypsin and chymotrypsin.
Lancet. 1966 Jul 23;2(7456):232. doi: 10.1016/s0140-6736(66)92526-8.
7
小鼠中的“天然”杀伤细胞。I. 对小鼠莫洛尼白血病细胞具有特异性的细胞毒性细胞。根据基因型的特异性和分布。
Eur J Immunol. 1975 Feb;5(2):112-7. doi: 10.1002/eji.1830050208.
8
Isolation of a protease inhibitor from tissues resistant to tumor invasion.
Hoppe Seylers Z Physiol Chem. 1977 Dec;358(12):1525-31. doi: 10.1515/bchm2.1977.358.2.1525.
9
乳腺纤溶酶原激活剂：与退化、激素调节的相关性以及正常组织与肿瘤组织的比较
Cell. 1979 Apr;16(4):929-40. doi: 10.1016/0092-8674(79)90108-9.
10
Decreased production of transforming virus and altered antigenic behaviour in cultured avian sarcoma cells.
J Gen Virol. 1979 Feb;42(2):255-64. doi: 10.1099/0022-1317-42-2-255.
Zotero 插件