纤溶酶原激活剂的促有丝分裂和免疫调节作用的进一步研究。
Further studies on the mitogenic and immune-modulating effects of plasminogen activator.
作者信息
Wainberg M A, Israel E, Margolese R G
出版信息
Immunology. 1982 Apr;45(4):715-20.
Abstract
Plasminogen activator (PA), an enzyme which is secreted in large quantities by certain types of tumour cells, is an apparent lymphocyte mitogen. Treatment of mouse spleen cells with anti-Thy-1.2 serum plus complement prevents responsiveness, indicating that T cells are being stimulated to divide. In addition to the foregoing, we have shown that PA has the capacity to interfere with certain types of cell-mediated cytotoxicity and natural killer cell reactions in which tumour cells are employed as targets. These results suggest that PA may play an immune-modulating role which may be of importance in tumour self-defense.
摘要
纤溶酶原激活剂（PA）是一种由某些类型的肿瘤细胞大量分泌的酶，它显然是一种淋巴细胞促有丝分裂原。用抗Thy-1.2血清加补体处理小鼠脾细胞可阻止其反应性，这表明T细胞正被刺激分裂。除上述情况外，我们还表明PA有能力干扰某些类型的以肿瘤细胞为靶标的细胞介导的细胞毒性和自然杀伤细胞反应。这些结果表明，PA可能发挥免疫调节作用，这在肿瘤自身防御中可能很重要。
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