De Benedictis G, Capalbo P, Dragone A
Comp Immunol Microbiol Infect Dis. 1984;7(1):35-42. doi: 10.1016/0147-9571(84)90014-6.
Alloimmunization of cattle revealed a polymorphism carried on a serum antigen displayed beta-electrophoretic mobility. A genetic test indicated that the antigen is inherited in a Mendelian manner, as product of a dominant allele at an autosomal locus. By immunochemical investigation the allotypic determinant was found to be located on IgA: there were in fact no differences between the peptidic map of the molecule carrying the allotypic determinant and that of IgA from positive sera. Moreover the peptidic map of IgA from sera lacking of the allotype resulted lacking of an anodic peptide, thus suggesting that the polymorphism is indeed due to such a peptide.
牛的同种免疫显示出一种多态性，该多态性存在于一种具有β电泳迁移率的血清抗原上。基因检测表明，该抗原以孟德尔方式遗传，是常染色体位点上一个显性等位基因的产物。通过免疫化学研究发现，同种异型决定簇位于IgA上：实际上，携带同种异型决定簇的分子的肽图谱与阳性血清中IgA的肽图谱之间没有差异。此外，缺乏该同种异型的血清中IgA的肽图谱显示缺少一条阳极肽，因此表明这种多态性确实是由这种肽引起的。
