Isozymes of glycogen synthase.

Antisera to rat skeletal muscle glycogen synthase failed to recognize liver glycogen synthase by electroblot analysis. The antisera recognized the enzyme in skeletal muscle, heart, fat, kidney, and brain. The results support the hypothesis that there are at least two isozymes of glycogen synthase, and that most tissues contain a form similar or identical to the skeletal muscle type. There is a virtual absence of the muscle-type enzyme in adult rat liver.