Saxe C L, Mendelson N H
Genetics. 1984 Aug;107(4):551-61. doi: 10.1093/genetics/107.4.551.
A search was made for the genes responsible for the production of helical macrofibers in the original collection of macrofiber-producing strains of B. subtilis. Two loci were identified: fibA, located between hisA and tag-1, and fibB, linked to cysB. fibA governs a short-lived division suppression phenomenon associated with the production of rudimentary fibers, whereas fibB appears to be responsible for a persistent division suppression and a more highly organized helical macrofiber. Both mutations are recovered from each of the original macrofiber-producing strains which also carried the div IV-B1 mutation responsible for minicell production. The latter mutation by itself is not sufficient, however, for the production of macrofibers. Other known mutations leading to division suppression that map in the same region are shown not to be allelic to fibA or fibB. Neither fib locus appears to be responsible for helix hand determination.
对枯草芽孢杆菌产生大纤维的原始菌株库中负责产生螺旋状大纤维的基因进行了搜索。鉴定出两个位点：fibA，位于hisA和tag-1之间；fibB，与cysB连锁。fibA控制与原始纤维产生相关的短暂分裂抑制现象，而fibB似乎负责持续的分裂抑制和更高度有序的螺旋状大纤维。这两种突变都从每个原始的产生大纤维的菌株中获得，这些菌株还携带负责产生微小细胞的div IV-B1突变。然而，后一种突变本身不足以产生大纤维。其他已知的导致分裂抑制且定位于同一区域的突变被证明与fibA或fibB不是等位基因。两个fib位点似乎都不负责螺旋方向的确定。
