Rabin D, Evans R M, Alexander A N, Doelle G C, Rivier J, Vale W, Liddle G W
J Androl. 1984 May-Jun;5(3):176-80. doi: 10.1002/j.1939-4640.1984.tb02390.x.
Eight normal male volunteers received an LHRH analog, 100 to 500 micrograms daily, for 20 weeks. Testosterone enanthate, 100 mg, was given by injection every second week. Sperm density fell to 5.5 X 10(6)/ml and to 0 in two of the subjects receiving 100 micrograms, but was unchanged in the third. Three of the subjects who received 500 micrograms displayed azoospermia, whereas the other two showed no significant change in sperm density. The reasons for the heterogeneity are not clear. Only one of the three nonresponders had testosterone values that were higher than the other subjects. Gonadotropin levels were similar in responders and nonresponders. It is possible that the response to LHRH analog in man is determined by the extent of the reduction in LH bioactivity.
八名正常男性志愿者连续20周每日接受100至500微克的促黄体生成素释放激素（LHRH）类似物。每两周注射一次100毫克庚酸睾酮。接受100微克剂量的两名受试者精子密度降至5.5×10⁶/毫升，其中两名受试者的精子密度降至零，但第三名受试者的精子密度没有变化。接受500微克剂量的三名受试者出现无精子症，而另外两名受试者的精子密度没有显著变化。这种异质性的原因尚不清楚。三名无反应者中只有一人的睾酮值高于其他受试者。反应者和无反应者的促性腺激素水平相似。人类对LHRH类似物的反应可能取决于促黄体生成素（LH）生物活性降低的程度。
