Sandholm L, Saxén L
J Clin Periodontol. 1984 Aug;11(7):459-66. doi: 10.1111/j.1600-051x.1984.tb01345.x.
Local immunoglobulin synthesis by the gingival plasma cells in 5 patients with juvenile periodontitis (JP) was compared to that in 5 patients with adult periodontitis (AP). The peroxidase-antiperoxidase method was used with specific antisera to alpha, gamma, and mu heavy chains and kappa and lambda light chains. The following relative distribution of plasma cells in JP/AP was found: IgA 22.7/19.5, IgG 75.6/78.5 IgM 1.7/2.0, kappa 55.5/53.5 and lambda 44.5/46.5, calculated as a % of their sum, indicating that the relative distribution of the different immunoglobulin chains was similar in both patient groups. The ratio light:heavy chains was 1.78 in JP and 1.72 in AP. The ratio kappa:lambda was 1.28 in JP and 1.17 in AP, similar to the known free kappa:free lambda chain ratio in normal serum (1.2). This indicates that the excessive staining for light chains is caused by a physiological overproduction of light chains rather than a pathological imbalance in the synthesis of immunoglobulins.
将5例青少年牙周炎（JP）患者牙龈浆细胞的局部免疫球蛋白合成情况与5例成人牙周炎（AP）患者进行比较。采用过氧化物酶 - 抗过氧化物酶法，使用针对α、γ和μ重链以及κ和λ轻链的特异性抗血清。发现JP/AP中浆细胞的以下相对分布情况：IgA为22.7/19.5，IgG为75.6/78.5，IgM为1.7/2.0，κ为55.5/53.5，λ为44.5/46.5，以它们总和的百分比计算，表明两个患者组中不同免疫球蛋白链的相对分布相似。JP中轻链与重链的比例为1.78，AP中为1.72。JP中κ与λ的比例为1.28，AP中为1.17，与正常血清中已知的游离κ/游离λ链比例（1.2）相似。这表明轻链的过度染色是由轻链的生理性过量产生引起的，而不是免疫球蛋白合成中的病理性失衡。
