Joachim F, Barber P, Newman H N, Osborn J
Department of Periodontology, University of London, U.K.
J Periodontal Res. 1990 Jan;25(1):49-59. doi: 10.1111/j.1600-0765.1990.tb01206.x.
This study analyses the ultrastructure of the plasma cell population of periodontitis-affected soft tissue close to the advancing front of interdental lesions. Biopsies from 20 patients and 3 control volunteers were examined: 5 with treated adult periodontitis (AP), 5 with untreated AP, 5 with treated juvenile or post-juvenile periodontitis (JP) and 5 with untreated JP. Plasma cell (PC) counts increased significantly (p less than 0.05) with lesion severity. They were absent from epithelium and sparse in the clinically healthy control specimens. Degenerate PC tended to be more numerous within JP tissue but differences were not significant (p greater than 0.05) when compared to AP. Intact plasma cells were never seen within JP superficial connective tissue. Russell bodies were small and few in number. The presence of degenerated plasma cells indicated normal formation and release of immunoglobulins within the tissues of AP and JP. Increased counts of degenerate PC and tissue destruction in JP suggested a correlation, possibly attributable to anti-collagen antibody secretion.
本研究分析了牙周炎累及的软组织中浆细胞群体的超微结构，这些软组织靠近牙间病变的进展前沿。对20例患者和3名对照志愿者的活检组织进行了检查：5例为治疗后的成人牙周炎（AP）患者，5例为未治疗的AP患者，5例为治疗后的青少年或青少年后期牙周炎（JP）患者，5例为未治疗的JP患者。浆细胞（PC）计数随病变严重程度显著增加（p小于0.05）。在临床上健康的对照标本中，上皮内未见浆细胞，且浆细胞稀少。在JP组织中，退化的PC往往更多，但与AP相比，差异不显著（p大于0.05）。在JP浅层结缔组织中从未见过完整的浆细胞。拉塞尔小体小且数量少。退化浆细胞的存在表明在AP和JP组织中免疫球蛋白的正常形成和释放。JP中退化PC计数增加和组织破坏提示存在相关性，可能归因于抗胶原抗体的分泌。
