苯妥英钠诱导成年男性对左旋多巴的生长激素反应增加。
Phenytoin-induced increase in growth hormone response to levodopa in adult males.
作者信息
D'Alessandro R, Cortelli P, Gallassi R, Ghisoli E, Montanaro N, Zoni E, Baruzzi A
出版信息
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):715-9. doi: 10.1136/jnnp.47.7.715.
Abstract
Growth hormone and prolactin response to levodopa were evaluated before and after long-term phenytoin treatment in five men with previously untreated partial epilepsy. After phenytoin treatment, growth hormone response to levodopa increased. There was a close relationship between growth hormone response to levodopa and plasma phenytoin concentrations. These findings suggest a phenytoin-induced dopaminergic activity at the hypothalamic-pituitary level in adult males.
摘要
在五名既往未经治疗的部分性癫痫男性患者中，评估了长期苯妥英治疗前后生长激素和催乳素对左旋多巴的反应。苯妥英治疗后，生长激素对左旋多巴的反应增强。生长激素对左旋多巴的反应与血浆苯妥英浓度之间存在密切关系。这些发现提示成年男性下丘脑-垂体水平存在苯妥英诱导的多巴胺能活性。
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