Fein G G, Jacobson J L, Jacobson S W, Schwartz P M, Dowler J K
J Pediatr. 1984 Aug;105(2):315-20. doi: 10.1016/s0022-3476(84)80139-0.
Polychlorinated biphenyls (PCBs), environmental pollutants that concentrate in the fatty tissue of predatory sports fish, cross the placenta in women exposed to ordinary dietary levels. Two hundred forty-two newborn infants whose mothers consumed moderate quantities of contaminated lake fish and 71 infants whose mothers did not each such fish were examined during the immediate postpartum period. PCB exposure, measured by both contaminated fish consumption and cord serum PCB levels, predicted lower birth weight and smaller head circumference. Exposed infants were 160 to 190 gm lighter than controls, and their heads were 0.6 to 0.7 cm smaller. Head circumference was disproportionately small in relation to both birth weight and gestational age. Control analyses showed that none of these effects was attributable to any of 37 potential confounding variables, including socioeconomic status, maternal age, smoking during pregnancy, and exposure to polybrominated biphenyls. These findings are consistent with earlier reports from studies in laboratory animals.
多氯联苯（PCBs）是一种环境污染物，会在掠食性食用鱼的脂肪组织中蓄积，普通饮食水平下接触多氯联苯的女性体内的多氯联苯会穿过胎盘。在产后即刻对242名母亲食用适量受污染湖鱼的新生儿和71名母亲未食用此类鱼的婴儿进行了检查。通过受污染鱼类消费量和脐带血血清多氯联苯水平来衡量的多氯联苯暴露，预示着出生体重较低和头围较小。暴露的婴儿比对照组轻160至190克，他们的头围小0.6至0.7厘米。相对于出生体重和胎龄，头围过小。对照分析表明，这些影响均不能归因于37个潜在的混杂变量中的任何一个，包括社会经济地位、母亲年龄、孕期吸烟以及多溴联苯暴露。这些发现与早期在实验动物研究中的报告一致。
