Wilkinson M
J Reprod Fertil. 1984 Jul;71(2):463-6. doi: 10.1530/jrf.0.0710463.
LHRH-stimulated LH and FSH secretion was studied in hemipituitaries, in vitro, obtained from several dystrophic mouse mutants (male: 129/ReJ-dy; 129B6F1/J-dy; C57BL/6J-dy and C57BL/6J-dy2J; female: 129B6F1/J-dy) and a dystrophic hamster mutant (male and female CHF-147). Without exception, pituitary tissue from dystrophic animals released significantly more FSH than did tissue obtained from controls. LH secretion was more variable; in the male mice released was inhibited, whereas in the male dystrophic hamsters secretion was elevated above normal. The female mouse mutant pituitary released more LH whereas in the female hamster LH secretion was normal. The reduction in body weight of the mutants studied could have contributed to the observations of impaired anterior pituitary function.
在体外对取自几种营养不良小鼠突变体（雄性：129/ReJ-dy；129B6F1/J-dy；C57BL/6J-dy和C57BL/6J-dy2J；雌性：129B6F1/J-dy）以及一种营养不良仓鼠突变体（雄性和雌性CHF-147）的半垂体进行了促性腺激素释放激素（LHRH）刺激的促黄体生成素（LH）和促卵泡生成素（FSH）分泌的研究。无一例外，来自营养不良动物的垂体组织释放的FSH明显多于对照组获得的组织。LH分泌变化更大；雄性小鼠的释放受到抑制，而雄性营养不良仓鼠的分泌高于正常水平。雌性小鼠突变体垂体释放更多LH，而雌性仓鼠的LH分泌正常。所研究突变体体重的减轻可能导致了垂体前叶功能受损的观察结果。
