Katoh-Semba R, Semba R, Kashiwamata S, Kato K
Department of Perinatology and Biochemistry, Institute for Developmental Research, Aichi, Japan.
J Mol Neurosci. 1993 Summer;4(2):107-15. doi: 10.1007/BF02782123.
An investigation was made of age-related changes in levels of the beta-subunit of nerve growth factor (beta-NGF) in selected tissues and of testosterone in serum in senescence-accelerated mice (SAM-P/8) and in the control mice (senesence-resistant mice; SAM-R/1). The concentrations of testosterone in serum were higher in SAM-P/8 than in SAM-R/1 at ages 2 and 4 mo. The level of beta-NGF in the thymus from SAM-R/1 increased with age, resulting in a statistically significant difference in its level between mice at ages 2 and 12 mo. By contrast, there was a transient increase in SAM-P/8 at around age 4 mo with a subsequent decrease. Consequently, significant differences were apparent in levels of beta-NGF between the two types of mouse at ages 2 and 4 mo. Similar results were obtained in the adrenal gland and testis. Compared to SAM-R/1 at age 2 mo, the average concentrations of beta-NGF in the hypophysis were higher in SAM-R/1 at ages 4 and 8 mo and in SAM-P/8 at all ages. In other tissues tested, no remarkable differences were detected. Our present results indicate that, in SAM-P/8, the elevation in levels of beta-NGF in the thymus, adrenal gland, testis, and hypophysis occurs in the early period of life compared to the control mice. Possible dysfunction of the disorder of hypophysis is discussed.
对快速老化小鼠（SAM-P/8）和对照小鼠（抗老化小鼠；SAM-R/1）特定组织中神经生长因子β亚基（β-NGF）水平以及血清中睾酮的年龄相关变化进行了研究。在2个月和4个月龄时，SAM-P/8血清中睾酮的浓度高于SAM-R/1。SAM-R/1胸腺中β-NGF的水平随年龄增加，导致2个月龄和12个月龄小鼠之间其水平存在统计学显著差异。相比之下，SAM-P/8在4个月龄左右出现短暂升高，随后下降。因此，在2个月龄和4个月龄时，两种类型小鼠的β-NGF水平存在明显差异。在肾上腺和睾丸中也获得了类似结果。与2个月龄的SAM-R/1相比，4个月龄和8个月龄的SAM-R/1以及所有年龄段的SAM-P/8垂体中β-NGF的平均浓度更高。在其他测试组织中，未检测到明显差异。我们目前的结果表明，与对照小鼠相比，在SAM-P/8中，胸腺、肾上腺、睾丸和垂体中β-NGF水平的升高发生在生命早期。讨论了垂体功能障碍的可能情况。
