Macková N, Misúrová E, Praslicka M
Neoplasma. 1978;25(2):163-9.
The histological picture and deoxyribonucleoprotein (DNP) content in the spleen of the white male Wistar rats continuously irradiated with the daily dose rates 9.57 mGy (1 R), 95.7 mGy (10 R), 478.5 mGy (50 R) and 657.0 mGy (100 R) were studied. The animals were examined within the day until 60 of irradiation. The number of lymphocytes permanently decreased at the daily dose rates 95.7 mGy and higher ones. The increased activity of reticulum with the simultaneous multiplication of the erythroid cells in the red pulp of spleen was observed at day 10 and 60 of irradiation with 9.57 mGy and 95,7 mGy. Simultaneously DNP content in spleen increased in accordance with the increased activity of reticulum and extramedullar erythropoiesis. The significant decrease in DNP content alter the onset of irradiation with the daily dose rates 478.5 mGy and 957.0 mGy was caused mainly by the fall of lymphocytes. The incidence of eosinophilic leukocytes increased from day 40 irradiation with the daily dose rates 9.57 mGy, 95.7 mGy and 478.5 mGy and decreased with the daily dose rate 957.0 mGy. The plasma cells tended to increase in accordance with the increasing accumulated dose of irradiation with all daily dose rates.
研究了以每日剂量率9.57毫戈瑞（1伦琴）、95.7毫戈瑞（10伦琴）、478.5毫戈瑞（50伦琴）和657.0毫戈瑞（100伦琴）持续照射的雄性白色Wistar大鼠脾脏的组织学图像和脱氧核糖核蛋白（DNP）含量。在照射60天内对动物进行检查。在每日剂量率为95.7毫戈瑞及更高剂量率时，淋巴细胞数量持续减少。在以9.57毫戈瑞和95.7毫戈瑞照射的第10天和第60天，观察到脾脏红髓中网状组织活性增加，同时红系细胞增殖。同时，脾脏中的DNP含量随着网状组织活性和髓外红细胞生成的增加而增加。在每日剂量率为478.5毫戈瑞和657.0毫戈瑞照射开始后，DNP含量显著下降，这主要是由于淋巴细胞减少所致。在每日剂量率为9.57毫戈瑞、95.7毫戈瑞和478.5毫戈瑞照射时，嗜酸性白细胞的发生率从照射第40天开始增加，而在每日剂量率为657.0毫戈瑞时则下降。在所有每日剂量率下，浆细胞倾向于随着累积照射剂量的增加而增加。
