肿瘤相关抗原对白细胞迁移的抑制作用及其血清修饰；IgA作为一种阻断因子。
Inhibition of leukocyte migration by tumor-associated antigen and its modification by serum; IgA as a blocking factor.
作者信息
Sipos J, Gábor V, Tóth Z
出版信息
Neoplasma. 1978;25(2):181-8.
PMID:643122
Abstract
Based on the investigations of patients the migration inhibition assay proved to be a useful method for the detection of antitumorous cellular immunity. Out of the twenty patients tested 15 gave migratory inhibitory effect against specific tumor antigen. In 8 cases out of the above 15 the blocking activity of sera has been proved. This blocking activity is bound to IgA subclass. The complement played an "unblocking" role. The modifying role of serum factors in cellular immunity against tumors was discussed.
摘要
基于对患者的调查，迁移抑制试验被证明是检测抗肿瘤细胞免疫的一种有用方法。在接受测试的20名患者中，有15名对特定肿瘤抗原有迁移抑制作用。在上述15例中的8例中，血清的阻断活性得到了证实。这种阻断活性与IgA亚类有关。补体起到了“解除阻断”的作用。讨论了血清因子在抗肿瘤细胞免疫中的调节作用。
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