de Meirleire F, Fauchere J L, Simon G
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):570-2.
We studied the pharmacokinetics of ticarcillin in cystic fibrosis patients. Concentrations of ticarcillin were assayed in serum and sputum samples from 11 children. We found that antibiotic serum concentrations were consistent with those reported in the literature. Ticarcillin half-life was shorter in patients than in controls. No direct correlation was found between concentrations in serum and those in sputum. Among six children with P. aeruginosa infection, ticarcillin levels in sputum were sufficient to eliminate P. aeruginosa in 50% of cases.
我们研究了替卡西林在囊性纤维化患者中的药代动力学。测定了11名儿童血清和痰液样本中替卡西林的浓度。我们发现抗生素血清浓度与文献报道的一致。患者中替卡西林的半衰期比对照组短。血清浓度与痰液浓度之间未发现直接相关性。在6名铜绿假单胞菌感染的儿童中，痰液中的替卡西林水平足以在50%的病例中清除铜绿假单胞菌。
