哌拉西林、替卡西林和羧苄西林药代动力学的比较研究。
Comparative study of piperacillin, ticarcillin, and carbenicillin pharmacokinetics.
作者信息
Meyers B R, Hirschman S Z, Strougo L, Srulevitch E
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):608-11. doi: 10.1128/AAC.17.4.608.
Abstract
Piperacillin, ticarcillin, and carbenicillin were administered intravenously to 10 healthy volunteers in a three-way, crossover study. The pharmacokinetics of the three drugs were in general quite similar. The peak serum concentration of piperacillin achieved at the end of a 30-min intravenous infusion was 63.5 +/- 27.6 microgram/ml. During the first 8 h, 67.5% of the dose of piperacillin was excreted in the urine, and the urinary concentration was extremely high. All three penicillins had high volumes of distribution. The serum half-life of the beta elimination phase of carbenicillin was lower than that of either piperacillin or ticarcillin. The volunteers experienced no adverse reactions from the administration of the drugs.
摘要
在一项三交叉研究中，对10名健康志愿者静脉注射哌拉西林、替卡西林和羧苄西林。这三种药物的药代动力学总体上非常相似。静脉输注30分钟结束时，哌拉西林的血清峰值浓度为63.5±27.6微克/毫升。在最初8小时内，哌拉西林剂量的67.5%经尿液排泄，且尿液浓度极高。所有三种青霉素的分布容积都很大。羧苄西林β消除相的血清半衰期低于哌拉西林或替卡西林。志愿者在用药过程中未出现不良反应。
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